Form: S-1/A

General form for registration of securities under the Securities Act of 1933

October 17, 2025

Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We hereby consent to the use in the Prospectus constituting a part of this Registration Statement of our report dated May 14, 2025, except the effects of the reverse stock split described in Note 2, as to which the date is October 17, 2025, relating to the consolidated financial statements of Evommune, Inc. (the Company), which is contained in that Prospectus. Our report contains an explanatory paragraph regarding the Company’s ability to continue as a going concern.

We also consent to the reference to us under the caption “Experts” in the Prospectus.

/s/ BDO USA, P.C.

New York, New York

October 17, 2025